Clemson football will face Notre Dame in a home-and-home series starting in 2027. It will mark Clemson's second home-and-home series with a non-ACC school.

Clemson and Notre Dame are set to announce a 12-year scheduling agreement that will pit the two college football powers against each other annually through 2038.

Notre Dame and Clemson already know each other pretty well in football. That relationship will become even more familiar in the future after the two college football powers announced a 12-year home-and-home scheduling agreement on Tuesday that will pit them against each other annually from 2027 through 2038.