To establish whether the effects of C1q on synapse elimination are mediated by the classical complement cascade, the authors examined another component of the cascade, C3. The expression of C3 in ...

By silencing C3, investigational ARO-C3 has the potential to treat complement-mediated renal diseases by modulating activation of the complement cascade. About the AROC3-1001 Phase 1/2a Study ...

investigational ARO-C3 has the potential to treat complement-mediated renal diseases by modulating the activation of the complement cascade. Pharmacodynamic effects: Maximum mean reduction in C3 ...

Previous work uncovered the role of the complement system in neuroinflammation and synaptic loss in neurodegenerative disorders such as Alzheimer’s disease (AD). The third component, C3, central in ...

A preclinical biotechnology company, spun out of The University of Manchester, has announced the completion of a €72 million finance deal to develop the treatment of a leading cause of blindness. The ...