To establish whether the effects of C1q on synapse elimination are mediated by the classical complement cascade, the authors examined another component of the cascade, C3. The expression of C3 in ...

Immunotherapy is increasingly becoming standard therapy in cancer, with technology, such as checkpoint inhibitors and cell ...

Fintel reports that on April 29, 2025, Cantor Fitzgerald initiated coverage of Apellis Pharmaceuticals (NasdaqGS:APLS) with a ...

Similar to the coagulation system, the complement system consists of a cascade of proteases that is ... CB 2782-PEG, Catalyst’s novel anti-C3 protease for the treatment of dry AMD, achieved ...

The cleavage of C5 into fragments C5a and C5b is a critical event during the complement cascade, as C5a is a potent pro-inflammatory anaphylatoxin capable of inducing cell migration, adhesion and ...