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Granzyme K identified as key trigger of complement system in autoimmune diseases
Their findings not only reshape the century-old understanding of the complement system but also open new avenues for therapies that could specifically block this harmful pathway in patients with ...
Nature5y
78 Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis
Mannan-binding lectin (MBL), M-, L- and H-ficolin recognize microorganisms and activate the complement system via MBL-associated serine proteases (MASPs). We investigated lectin pathway cord blood ...
BioWorld4d
C3-targeting siRNA shows promise for Alzheimer’s: findings from cynomolgus monkey study
Previous work uncovered the role of the complement system in neuroinflammation and synaptic loss in neurodegenerative disorders such as Alzheimer’s disease (AD). The third component, C3, central in ...
Nature2y
The potential role of complement in cardiac surgery-associated acute kidney injury
In recent years, the complement system has been implicated in the pathophysiology and progression of many disorders, notably modulating inflammation and causing endothelial and organ damage 1.