Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are ...

But the complement system is an oft-overlooked part of the immune system that could be exploited to create new therapies.

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The findings suggest a dysregulation of the complement pathway, a part of the immune system, and the blood clotting pathways in individuals with long COVID at six months.

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity. This significantly ...

Additionally, this acute-phase protein is involved in in the activation of the complement system via the classic pathway. Acute phase proteins are an integral part of the complement pathway in turn ...

How the Complement System Affects Your Kidneys When you have C3 glomerulopathy, your alternative complement system is overactive.

Researchers have pinpointed a brain protein that could offer a fresh target in the battle against Alzheimer's.

C3G and IC-MPGN are rare kidney conditions. They occur when a part of the immune system, called the complement system, doesn’t work as it should.

These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA ...

The Lectin Pathway of Complement Activation. Endocytic pattern-recognition receptors occur on the surface of phagocytes.