Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can ...

This pathway is involved in a variety ... the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding (shown in red for one of the monomers).

The ancient Wnt signalling pathway controls many of the processes ... linked to loss-of-funtion mutations in the Wnt receptor FZ4 (Frizzled 4). Loss-of-function mutations in WNT3 cause tetra ...

In the canonical pathway, Wnt ligands bind to Frizzled receptors, stabilizing β-catenin, which accumulates in the cytoplasm and enters the nucleus. In the nucleus, β-catenin activates downstream ...

Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis.

Among the pathways originating from ectopic endometrial stromal cells, the non-canonical WNT pathway, which usually regulates ... which acts on the ovarian cells through the receptor Frizzled-1. “We ...