In patients with IgG4-related disease, the serum IgG4 concentration is typically high and often very, very high. Example, elevated up to five or 10 times the upper limit of normal is not unusual ...

Relevant biomarkers include cytokines and targets such as IL-4, IgE, IL-5, IL-13, IL-33, and TSLP (Figure 2). A number of targeted drugs are currently available, including lebrikizumab, dupilumab, and ...

IgG4-related disease is a multifaceted, systemic fibroinflammatory condition that can affect virtually any organ, with autoimmune pancreatitis representing one of its most well‐characterised ...

Investigators in Argentina recently examined a small subset of patients with immunoglobulin G4-related disease (IgG4-RD) and pulmonary findings to learn more about this immune-mediated, multiorgan ...

So, autoimmune pancreatitis, which has gone by a number of different names for the past several decades, is, in fact, one of the most important manifestations of IgG4-related disease. So, IgG4 ...

In a paper published in Science Bulletin, the research team led by Professor Wen Zhang from the Department of Rheumatology and Immunology at Peking Union Medical College Hospital (PUMCH) has made ...

Following the nod, Uplizna became the first and only drug approved by the FDA for the treatment of IgG4-RD, a chronic disease with a significant unmet medical need.

An elderly man with immunoglobulin G4-related disease (IgG4-RD) with kidney involvement and monoclonal gammopathy was successfully treated with corticosteroid therapy. This case report was published ...

Zenas BioPharma's obexelimab Phase 3 trial in IgG4-RD is fully enrolled, with data expected by late 2025. Wedbush gives ZBIO an "outperform" rating with a $35 price target. Discover the top trade ...