GenAI offers a realistic path forward in tackling previously undruggable targets, with the potential to reshape the entire ...

Although several types of excitable cells exist — including neurons, muscle cells, and touch receptor cells — all of them use ion channel receptors to convert chemical or mechanical messages ...

In a new study, a team led by medical researchers at The Ohio State University has determined that these vesicles contain an ion channel—a protein that opens a corridor allowing electrical ...

View Full Profile. Learn about our Editorial Policies. The elusiveness of single ion channels intrigued researchers for another quarter of a century. In his youth, Erwin Neher, now a biophysicist at ...

Today it seems self-evident that neurons make their electrical signals by opening gates of water-filled pores (ion channels) in the plasma membrane. But it was not always so. Remarkably ...

Researchers have been studying TRPM8 ion channels in order to better understand their complex functions and develop innovative therapeutic approaches. An LMU research team led by Professor Michael ...

In plants, guard cells control the stomatal opening by expanding and contracting through ion flux. When a plant senses light, a signal is sent to the guard cell to increase its ion content, which ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

This study addresses the structural basis of voltage-activation of BK channels using atomistic simulations of several microseconds, to assess conformational changes that underlie both voltage-sensing ...

Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are ...