SANTA CLARA, Calif. — Some kids are just born to run. Isaac Guerendo’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. ... When the injury bug bites the 49ers, it takes a good chunk.

Getty 49ers’ running back Isaac Guerendo vs. the Dallas Cowboys Guerendo has five runs of 10-plus yards in 2024, including a 76-yarder to clinch a win against Seattle.

49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources.

The 49ers placed six players on their active/physically unable to perform list Friday, including wide receivers Brandon Aiyuk ...

In the fourth quarter, Guerendo departed with a foot injury and Shanahan said the 49ers were gathering information and hoping for the best. “I thought Isaac looked real good today,” Shanahan said.

Rookie Isaac Guerendo has been elevated to the 49ers’ starting running back after San Francisco had to put both Christian McCaffrey and backup Jordan Mason on the IR on the same day.. The news ...

Why tailback Isaac Guerendo is so enticing to the 49ers. After the late July hamstring injury, Turner’s focus was to keep Guerendo in a positive headspace.

Just a week ago, it seemed like Isaac Guerendo might not make the 49ers' 53-man roster. Now, it seems like he'll be their primary kick returner. That's how much can change in a few days.

The 49ers wouldn't have beaten the Seahawks this past Thursday night without rookie running back Isaac Guerendo. The 49ers had a 20-point lead, but starting running back Jordan Mason left the game ...