Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after hurting his foot?

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest on his status.

The 49ers placed six players on their active/physically unable to perform list Friday, including wide receivers Brandon Aiyuk ...

Is Isaac Guerendo playing today? 49ers injury update Despite entering the primetime clash with a questionable tag, Guerendo "plans to play," per ESPN's Adam Schefter.

49ers 53-man roster projection: Did Jacob Cowing, Isaac Guerendo secure their roles? “After changing direction and all that stuff, I probably ran about 140 yards,” Guerendo said in the locker ...

The 49ers wouldn't have beaten the Seahawks this past Thursday night without rookie running back Isaac Guerendo. The 49ers had a 20-point lead, but starting running back Jordan Mason left the game ...

Rookie Isaac Guerendo has been elevated to the 49ers' starting running back after San Francisco had to put both Christian McCaffrey and backup Jordan Mason on the IR on the same day.

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of the Year.

49ers’ Guerendo flashes impressive versatility in starting debut vs. Bears, downplays foot injury With Christian McCaffrey and Jordan Mason out for the season, Isaac Guerendo stepped up in ...

Just a week ago, it seemed like Isaac Guerendo might not make the 49ers' 53-man roster. Now, it seems like he'll be their primary kick returner. That's how much can change in a few days.

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after hurting his foot?