The Spartans and Rebels will take the floor first on Friday in a pair of Sweet 16 matchups in Atlanta as part of the South Region. The winner of this matchup will move on to face the winner of No. 1 seed Auburn and No. 5 seed Michigan in the Elite Eight on Sunday.

Four teams are already locked into the NCAA men's tournament Elite Eight. Four more must earn their place. Breaking down Friday's Sweet 16 matchups.

For the 16th time during his 30 seasons as head coach of Michigan State basketball, Tom Izzo and his Spartans have advanced to the Sweet 16 round of March Madness. Izzo and his teams are 10-5 in Sweet 16 play of the NCAA tournament, and their victories include a 75-58 win over Syracuse on their way to a national championship in 2000.

It’s the Ole Miss Rebels vs Michigan State in the March Madness bracket. Here’s our prediction for the 2025 NCAA tournament basketball game.