Dr. Cox: Uhh, Mr. Radford, do I understand you have pain issues but you don’t want physical therapy? Mr. Radford: I just don’t have it in me.

Recording its first episode in 2006, the L.A.-based Uhh Yeah Dude predates just about every other podcast out there. The formula is simple: Hosts Seth Romatelli and Jonathan Larroquette—his dad ...