In this article, ACROBiosystems discusses how the complement cascade and it's various components could potentially be leveraged for therapeutic potential in COVID-19, cancer and general inflammation.

SNY's SAR446597, a one-time intravitreal gene therapy, secures FDA fast track tag for geographic atrophy due to age-related ...

The FDA granted fast track designation to SAR446597, an intravitreal gene therapy for the treatment of geographic atrophy due ...

The complement cascade can be initiated by three distinct pathways: the classical, lectin, and alternative. The team estimated the upstream complement factors to determine the predominant factor ...

The complement cascade is a cellular pathway associated with the development and progression of GA (Figure 1-7). The complement system consists of more than 30 circulating systemic proteins that ...

When C1q, the initiating factor of the complement cascade, was eliminated from these animals—either via genetic deletion or with antibody blocking—the researchers noted that synapses in the ...

Acute chest syndrome associated with sickle cell is driven by the abnormal activation of the complement cascade, per a study.

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are ...

With this ability to focus on 2 key pathways, ... The NOTCH4, CD34, and CD46 loci have known complement cascade effects and are hypothesized to play a role in the pathogenesis of CSR.