Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis.

Complement was discovered by Jules Bordet, who was awarded the 1919 Nobel Prize in medicine, and named by Paul Ehrlich in 1899. Three pathways have now been described in the complement system ...

The complement system activation helps elicit an immune response against pathogens or damaged tissue. During the activation of the complement pathway, the plasma proteins belonging to the ...

Disruption of the complement system appears to precede the onset of islet autoimmunity (IA), making it a potential early warning sign of type 1 diabetes (T1D), according to a new report.. The ...

In COVID-19 patients, the complement system was one of the most highly induced pathways in lung epithelial cells infected by SARS-CoV-2, ...

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system. Omeros controls the worldwide rights to MASP-2 ...

In one of these mice models, a lack of Nptx2 was tied to increased activity of the complement system as well as the destruction of synapses by the brain’s immune cells.

When you have C3 glomerulopathy, your alternative complement system is overactive. When it reaches this state of high alert, it starts to break down proteins in your body called complement 3 (C3 ...