Several observations from preclinical and short-term clinical studies support a role for sildenafil in the treatment of heart failure patients. The following discussion briefly considers each of ...

We found independent progenitors emerging at specific times, contributing exclusively to left ventricle/atrioventricular canal (LV/AVC) or atrial myocytes. LV/AVC progenitors differentiated early to ...

The measurement of CK, especially the isoenzyme CK-MB, is considered as an alternative to Tn measurement to detect heart injury, but only if this latter is not available. Blood CK-MB may be ...

Circular RNAs (circRNAs) have been gradually revealed to regulate the progression of heart disease in depth, showing their clinical significance. However, a mass of cardiac circRNAs still has not been ...

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells change their metabolic profiles in ...

Repeated tests lead to at a set of parameter values that allow faithful reproduction of range of functional variables of cardiac myocytes. We then apply the model to studies of OM. Results and ...

(1) Modeling of Na and Ca homeostasis in atrial and ventricular myocytes, to predict the consequences of local [Ca]i and [Na]i signaling in cardiac excitation-contraction in normal and diseased states ...

1 First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ...