Its flagship project was intepirdine, an experimental 5-HT6 receptor antagonist it acquired ... deals involving a pair of gene therapies for GM1 and GM2 gangliosidosis – AXO-AAV-GM1 and AXO ...

Ophthalmology: ptosis (mitochondrial disorders, Menkes syndrome), retinal degeneration (grey matter disease), optic atrophy (white matter disease), cherry-red spots (GM1/2 gangliosidosis ...

This indicates that GLP-1 receptor agonists lead to greater reduction in overall body fat than that in muscle mass, resulting in an overall body fat percentage decrease of around 4.5%.

Piperine stimulates the pain receptors of rats and other mammals, causing them to sneeze, cough, and "scurry away." A cluttered space is an ideal habitat for a rat, especially in garages where ...

Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world. Atherosclerosis, or the buildup of plaque in the ...

In one study of unselected patients with epilepsy, 6.25% had increased serum anti-GM1 antibodies.47 All had complex partial epilepsy with secondary generalisation, drug resistance, psychiatric ...

Specifically, Auletta highlights the emerging science in stem cell transplants and cell therapies, including treatments like chimeric antigen receptor (CAR) T-cell therapy. He also discussed topics ...

We present a patient with clinical features consistent with BBE and positive anti-GM1 and anti-GD1a antibodies. A diagnostic approach to the acutely unwell patient with brainstem encephalitis is ...

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium ...

Bangladesh is a nation with a vast river system and a dense population, and water contamination is a major environmental and public health issue in the country (Figure 1). The country’s water ...