Most interestingly the keyboard will support game keys layout, like the screenshot of a Quake 3 setup to the right. There are a couple of questions still in the air, ...

Custom layouts can get cramped, and I can make things more manageable by adjusting the key size. ... The Keys Cafe Play keyboard game utility is more of a fun feature and isn’t for customization.

ROCCAT's new Isku FX Multicolor Gaming Keyboard features 36 macro keys and backlighting options in 16.8 million colors that correspond to in-game actions.

Both of these have a standard keyboard layout (though, of course, you can make things less standard by binding any key to any macro function) with all of the standard game hotkeys clearly labeled.