Branched-chain amino acids (BCAAs), include the essential amino acids leucine, isoleucine, and valine. BCAAs differ from other amino acids because they have a branched structure and are the only ...

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LAT1/4F2hc heterodimeric complex is a major route for the transport of large neutral essential amino acids through the plasma membrane. Although it has been shown that LAT1/4F2hc is highly ...

1 Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China 2 Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ...

TLX101 (131 I-iodofalan or 131 I-IPA) is a systemically administered targeted radiation therapy that targets L-type amino acid transporter 1 (LAT1), which is typically over-expressed in glioblastoma.

a radiation therapy that targets L-type amino acid transporter (LAT1), along with external beam radiation therapy (EBRT). The primary endpoint of the study was safety and tolerability, and Telix ...

TLX101 targets LAT1 protein on glioblastoma cells and can cross the blood-brain barrier, offering a novel approach to treatment. TLX101 has orphan drug status in the US and Europe but is still under ...

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, ...

Department of Pharmacology and Toxicology, Center for Addiction Sciences and Therapeutics, University of Texas Medical Branch, Galveston, Texas 77555, United States ...