The complement system consists of more than 30 circulating systemic proteins that are associated with inflammation, opsonization, phagocytosis ... aberrant turnover of lysosomes and activation ...

This suggested to Haass that TREM2-high microglia might be maxed out in their capacity for phagocytosis. Would TREM2 agonism ... and processing in lysosomes ramped up following TREM2 agonism in ...

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for ...

These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down various substances ready for disposal, including proteins, nucleic ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for ...

The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...