Unsurprisingly, TTLL11 overexpression failed to rescue the rostral motor axon defects of spastin null mutants (Fig. 8E–G), identifying TTLL11 as a selective regulator of spastin-driven motor axon ...

Acute flaccid paralysis in children is a medical emergency that can progress to respiratory failure within hours or days, ...

Doctors and genetic researchers at The University of Manchester have discovered that changes in a gene leads to severe nerve damage in children following a mild bout of infection.

Furthermore, we have discovered that mouse Sertm2 may modulate peripheral GDNF signaling. Mice lacking A730046J19Rik containing Sertm2 exhibit defects in axonal arborization, particularly in the Etv4 ...

Unlike the brain and spinal cord, peripheral nerve cells, whose long extensions reach the skin and internal organs, are capable of regenerating after injury. This is why injuries to the central ...

The precise clustering of ion channels at axon initial segments (AIS) and nodes of Ranvier is essential for axonal excitability and rapid action potential propagation. Among the axonal ion channels, ...