Now, researchers have harnessed the power of a resident drug courier, i.e., microglia. Researchers genetically engineered human iPSC-microglia to deliver neprilysin when the cells are near amyloid ...

The article presents important findings describing the role of IL27 in maintaining HSCs at steady state, and in emergency haematopoiesis in response to T. goodii by limiting the inflammatory monocyte ...

Signaling through the TREM2 receptor fuels an ever-growing list of known microglial functions in the brain, and gene variants that hobble TREM2 signaling beckon Alzheimer’s disease. Ergo, activating ...

Atrial fibrillation (AF) is increasing in prevalence and linked to higher morbidity and mortality rates. Emerging evidence implicates inflammation as a key driver of AF pathogenesis. 1 Our study aimed ...

This important work advances our understanding of the aging trajectory and heterogeneity of hippocampal microglia. The authors provide an in-depth characterization of microglia in young and old mice ...

SAN DIEGO -- A single dose of investigational tanruprubart resulted in rapid, sustained improvement in disability compared with placebo in patients with Guillain-Barré syndrome (GBS), a phase III ...

Researchers have discovered that the immune checkpoint molecule Tim-3 plays a key role in microglial function in the brain and may contribute to Alzheimer’s disease by hindering plaque clearance.

Summary: New research reveals that the immune checkpoint molecule Tim-3 plays a critical role in how microglia, the brain’s immune cells, respond to Alzheimer’s disease. While Tim-3 normally helps ...

Tanruprubart also elicited “more complete recovery” over standard care. Tanruprubart is a monoclonal antibody that works by targeting and blocking the C1q protein in the peripheral and central nervous ...

LI Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presence of microglia in the peripheral nervous system (PNS) and identified ...