Inhibiting the complement C3/C3a receptor (C3aR) pathway reduces visual and optic nerve impairment in neuromyelitis optica spectrum disorder (NMOSD), showed a new study conducted in a rat model of the ...

These animal studies allowed for a detailed examination of how signals travel through nerve pathways and how brain cells respond. This helped her begin to uncover how different areas of the brain ...

Each of those three pathways has a unique enzyme that initiates the complement cascade. We found that granzyme K works differently from other proteases. It is independent because it comes from CD8 ...

KALIA XIONG BEGAN HER CAREER AS CAPITOL PATHWAYS INTERN. >> BACK IN 2016, WHEN I STARTED, ON ONE OF THE FIRST DAYS OF THE PROGRAM, WE HAD A CAPITOL TOUR. SO WALKED THESE SAME HALLS. IT WAS VERY ...

While interindividual variations in concentration and function of coagulation cascade proteins are established risk factors for venous thromboembolism (VTE), their associations with arterial ischemic ...

Three distinct pathways can be activated ... and of C1q and the classical complement cascade as central effectors of the pathogenic effects of these antibodies, likely through both ...

Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors ...