New research uncovers an immune pathway driving acute chest syndrome in sickle cell disease; blocking it with approved drugs ...

Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway. Most of the proteins and glycoproteins that ...

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are ...

The findings suggest a dysregulation of the complement pathway, a part of the immune system, and the blood clotting pathways in individuals with long COVID at six months.

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

Additionally, this acute-phase protein is involved in in the activation of the complement system via the classic pathway. Acute phase proteins are an integral part of the complement pathway in turn ...

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How the Complement System Affects Your Kidneys When you have C3 glomerulopathy, your alternative complement system is overactive.

Researchers have pinpointed a brain protein that could offer a fresh target in the battle against Alzheimer's.

These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA ...

As new complement therapeutics are approved, we will learn more about the nuances of the complement system. These nuances aren't apparent in a normal functioning situation.