In the first round of optimization compound 8, with a cyclopentane core, was chosen as the most promising agonist (β-arrestin recruitment EC50 = 20 nM and calcium mobilization EC50 = 740 nM).
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
H 2 O (LC-MS grade, Merck), ETHF (97%, Tokyo Chemical Industry), 14ECP (98%, Alfa Aesar), and 12ECH (98%, Tokyo Chemical Industry) and were used as received. High-purity CH 4 (99.95%) and N 2 (99.99%) ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results