Using a combination of cell-based and mouse models, the authors provide compelling evidence showing that arginine restriction in the microenvironment disrupts lipid homeostasis in PDAC, resulting in ...

More information: Ying Chen et al, A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines, Nature Methods (2025). DOI: 10.1038/s41592-025-02623-4 ...

at single-cell level resolution, in human CFs. The image analysis pipeline processed each fluorescence channel (Figure [D]). CellProfiler was used to adjust for illumination artifacts, segment ...

The work to create viable human tissue from scratch — whether that’s cells or an entire organ — has not stopped. With cell-based “bioinks” and three-dimensional (3D) bioprinters ...

These cell lines and future research can help us uncover those mechanisms, and that could lead to new therapies for human diseases." A cell line is a population of cells that are cultured and ...

The papers, published in Nature this week, investigate the use of cells derived from human induced pluripotent stem cells and human embryonic stem cells, respectively. However, further research is ...

Researchers have found that sound can influence cells directly, including suppressing fat cell development and activating certain genes – suggesting a future where acoustic therapy could aid medicine.

Methods: Using 18 public single-cell RNA-seq and single-nuclear RNA-seq data of human and mouse hearts, we illustrate the entire atlas of FFAR2/3 distribution in different regions and cell types in ...

For decades, animal models have been the gold standard for preclinical testing of potential drugs. Yet, even the best animal models are not perfect. For example, small rodent species with ...