Antibiotics increase the gut oxygen levels and favor growth of harmful fungi. Chemically restoring intestinal gut hypoxia ...

2006). Using DNA microarrays, these investigators examined changes in gene expression at a global level in different cell types. In looking for a signature of hypoxia, the researchers compared ...

Yet for decades the precise workings were largely a mystery. Scientists knew that in low oxygen situations, or hypoxia, cells trigger a cascade of physiological events to restore oxygen ...

Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most ...

Resistant cancer cells exhibit traits like drug efflux, enhanced DNA repair, protein homeostasis, and an immunosuppressive ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Haemostasis (clot formation) halts the bleeding, and the body quickly forms a blood clot in response to injury. Inflammation ...

By lowering the media volume, and thus increasing the pericellular oxygen, Tan observed lowered hypoxia signaling and transcriptional rewiring that recapitulated a healthier adipocyte cell model.

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...