Mechanistically, FTY720 promoted the redistribution of ABCA1 (ATP-binding cassette transporter A1) from lysosomes to the cell membrane in microglia via TREM2, which facilitated cholesterol efflux and ...

The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down various substances ready for disposal, including proteins, nucleic ...

Department of Biospectroscopy and Bioelectrochemistry, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio av. 7, Vilnius LT-10257, Lithuania ...

Variants in Commander genes contribute to PD The study discovered that a group of 16 proteins, called Commander, comes together to play a previously unrecognized role in delivering specific proteins ...

These harmful variants reduce the activity of an enzyme called glucocerebrosidase (GCase), which is important for cells' recycling process in lysosomes. However, it has been unknown why some ...