Kyle Manzardo gave Cleveland the lead with a two-run single in the fourth, but Jackson Holliday tied the score with a solo home run in the sixth.

The Baltimore Orioles’ bullpen, once the lone source of stability for the struggling ballclub, has become a glaring problem over the past few weeks. After entering play Wednesday with the highest bullpen ERA in the majors this month at 6.

The Guardians are now 4-1 since the All-Star break and 10-2 since their 10-game skid following a second consecutive win against the Orioles.

The Guardians took the second of the four-game series with the Orioles, 6-3, a day after winning the opener, 10-5. Cleveland is on a three-game winning streak, 4-1 in the past five and 8-2 over the last 10, so the Guardians are getting hot, while the O’s are 1-6 in the last seven.

Preview the July 23 matchup between the Cleveland Guardians and Baltimore Orioles with odds over/under, game spread, betting lines and more.

Baltimore’s Ryan O’Hearn, with two out in the third, sent a grounder to third baseman Jose Ramirez. Santana tried to scoop Ramirez’s throw, but it hit his glove and fell out. Former Guardian Ramon Laureano, the next batter, added an extra sting to the error by homering off Tanner Bibee for a 5-3 lead.

Jose Ramirez hit a three-run homer and Bo Naylor and Kyle Manzardo had solo shots as the Cleveland Guardians beat the visiting Baltimore Orioles 10-5 in their series opener Monday night.