gut.bmj4d
Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease
Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...
gut.bmj4d
Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders
The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific ...
gut.bmj1d
P131 Incidence and prevalence of inflammatory bowel disease in UK primary care: a cohort study
Introduction Studies describing the epidemiology of inflammatory bowel disease (IBD) in the UK have been limited by small sample size and low generalisability. We describe temporal trends in the ...
gut.bmj1d
Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn’s disease (ANDANTE I and II)
Objective Neutralising pro-inflammatory interleukin-6 (IL-6) may effectively treat Crohn’s disease (CD). Effects of PF-04236921, an anti-IL-6 antibody, in adults with CD are reported. Results 247 ...
gut.bmj3d
Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment
Objective Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial for pre-metastatic ...
gut.bmj13d
Guidelines for the management of iron deficiency anaemia
Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...
gut.bmj4d
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel ...
gut.bmj3d
Optimal glycaemic control and the reduced risk of colorectal adenoma and cancer in patients with diabetes: a population-based cohort study
Correspondence to Dr Ka Shing Cheung, Department of Medicine, The University of Hong Kong, Hong Kong 999077, Hong Kong; cks634{at}hku.hk; Prof Wai-Kay Seto; wkseto{at}hku.hk Objective Whether varying ...
gut.bmj6d
The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
4 Department of Hepatogastroenterology, Hopital Claude Huriez, CHRU Lille, France Correspondence to: Professor J-F Colombel Department of Hepato-Gastroenterology, Hopital Claude Huriez, CHRU de Lille, ...
gut.bmj4d
Global patterns and trends in colorectal cancer incidence in young adults
Objective Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis ...
gut.bmj2d
The IL23 axis plays a key role in the pathogenesis of IBD
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel ...