κWhen microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

Machine learning software sharpens the diagnostic utility of FDG PET scans. StateViewer told apart nine neurodegenerative diseases with 93 percent accuracy. Using the program made radiologists three ...

p-Tau217 might be the Benjamin Button of biomarkers—starting off old and ending up young. Seriously, p-tau217 is unusually high at birth before waning with age, scientists report. In a cross-sectional ...

Two studies analyzed tau-PET scans from thousands of participants in dozens of cohorts. Tangle prevalence increased with age among cognitively normal people, but decreased among those with dementia.

Every participant in the Dutch 100-Plus study is, by definition, exceptional. Just to qualify for enrollment, they must have remained cognitively healthy even after logging 100 laps around the sun.

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

Over the last 40 years, age-adjusted dementia prevalence in the U.S. has dropped by two-thirds. This predicts a 25 percent rise in total dementia cases by 2050, due to population aging. The findings ...

On Tuesday September 10, Francisco Lopera died of cancer at his home in Medellin, Colombia. He was 73, and only just beginning to see his life’s work come to fruition. In fact, Lopera still had much ...

Other news from AAIC? Long-term lecanemab dosing in open-label extensions now goes out to three years, and continues to support the idea that the antibody slows disease progression. On cognitive ...

Delivered by a virus, CRISPR pulled an endosomal targeting motif off APP in mouse brain. This shifted APP processing away from β-secretase cleavage. Plaque growth, lysosomal dysfunction, gliosis, and ...

Crafting a PET tracer to detect α-synuclein deposits in the brain has been an uphill struggle. Now, scientists led by Hironobu Endo and Makoto Higuchi at the National Institutes for Quantum Science ...