2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting.

Oct 3, 2024 · 1. In this randomized controlled trial, among patients with moderately to severely active ulcerative colitis, tulisokibart, a monoclonal antibody directed against TL1A, more effectively induced clinical remission compared with placebo. 2. Compared with placebo, the tulisokibart group consistently showed benefits in clinical response, endoscopic improvement, histologic improvement, symptomatic ...

Jun 23, 2013 · Image: PD 1. The EVAR II trial compared endovascular abdominal aortic aneurysm repair with no intervention in patients unsuitable for the open procedure. 2. There were significantly fewer aneurysm-related deaths in the endovascular group, compared to no intervention. 3. The rates of complication and reintervention were similar to the rates observed in EVAR I. Original

Oct 2, 2024 · 1. In this randomized controlled trial, among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day resulted in no reduction in risk of hospitalization or death within one year compared with oxygen therapy for 15 hours per day. 2. Oxygen therapy for 15 versus 24 hours per day was associated with

Nov 16, 2024 · 1. In this randomized clinical trial comparing the use of pelvic floor muscle training (PFMT) alone to PFMT with a biofeedback (BF) device, the use of PFMT with BF was superior in reducing stress urinary incontinence (SUI) in postpartum women. Evidence Rating Level: 1 (Excellent) Stress urinary incontinence (SUI) is a pelvic floor dysfunction disorder

Dec 16, 2024 · 1. Median progression-free survival was 9.4 months in the imlunestrant–abemaciclib group vs 5.5 months in the imlunestrant group with HR 0.57 (significant) and 5.6 months in the imlunestrant group vs 5.5 months in the standard-therapy group with HR 0.87 (non-significant). 2. With regards to safety, adverse …

Feb 2, 2022 · 1. GLP-1 receptor agonists, such as semaglutide, and phentermine-topiramate were shown to cause the greatest percent decrease in body weight. 2. GLP-1 receptor agonists, phentermine-topiramate, and naltrexone-bupropion were also associated with increased adverse effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Over two-thirds of Americans are considered to be in the overweight or ...

Nov 26, 2024 · 1. In this randomized controlled trial of patients with heart failure and mildly decreased or preserved ejection fraction, finerenone treatment was associated with lower rates of worsening heart failure events. 2. Finerenone treatment was not associated with an increase in serious adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Finerenone, a nonsteroidal mineralocorticoid ...

Nov 25, 2024 · 1. In this randomized controlled trial, among adults diagnosed with chronic myeloid leukemia (CML), asciminib demonstrated a significantly higher major molecular response (MMR) rate compared to investigator-selected tyrosine kinase inhibitors (TKIs). 2. The safety profile of asciminib was favorable, with fewer grade 3 or higher …

Dec 11, 2024 · 1. Early DOAC therapy within 4 days was non-inferior to delayed therapy for the composite outcome of recurrent ischemic or unclassified stroke, symptomatic intracranial hemorrhage, and systemic embolism at 90 days. Evidence Rating Level: 1 (Excellent) Study Rundown: The optimal timing for starting anticoagulation in patients with acute ischemic stroke and atrial fibrillation remains unclear,